Drug Candidate Marketplace

Drug Candidate Marketplace lists the information of drug candidates, therapeutic targets and drug discovery technologies. Visitors can use search functions based on the interests and needs and download the list. If you have a drug candidates, therapeutic targets and drug discovery technologies that you are interested in and would like to gain more information, please contact us by clicking the inquiry button. Additional information will be provided to you.

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Date Candidate Mechanism of action Indication Route Modality Development stage Note
04/02/21 GEM241 Analyzer of EEG algorithm by AI Prediction of seizures in epilepsy patients Ear wearable Medical device On Market ・A personalized ear-wearable non-invasive small medical device which detects changes in EEG pattern by AI algorithm that alerts seizure minimum one minute before it occurs to patients and caregivers.
・It records brain activities through the ear canal and uses Big Data.
・By predicting the seizure before it occurs, the device will prevent accidents and reduce injuries, emergencies, and deaths.
・Also, it reduces emotional impact such as anxiety/depression and increases de quality of life.
・Big Data treatment can help doctors and medical society to better understand the illness and perform patinets' follow-up.
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03/26/21 GEM117 Induction of apoptosis in adipocyte Lipolysis, non-surgical fat reduction, Diabetes s.c. Small molecule
Phase 2a completed · GEM117 specifically induce apoptosis on local injection site adipocyte
· Phase 1 showed great safety without drug-related SAE in 40 healthy volunteers
· In the Phase 2a study (n=39), GEM117 showed significant dose-dependent lipolysis effects and reduced an average of 24% local fat volume. The safety profile was similar as observed in the Phase 1 study.
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03/24/21 GEM240 Genetically modified adipocytes Genetic diseases and intractable diseases Transー               plant Gene and Cell therapy Phase 1 Genetically modified adipocytes for gene therapy and regenerative therapy.
It is developed for the treatment of various genetic diseases and metabolic disorders. It shows sustainable and stable efficacy or secretion of transduced gene products from the implant of GEM240.
GEM240 is incomparable and patient-friendly.
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02/26/21 GEM-CVD08 An anti-SARS-COV-2 S1 RBD antibody COVID-19 i.v. Protein Phase-1 > 10 fold higher binding affinity and >50 fold more potent blocking potency than soluble hACE2-Fc.
Neutralize authentic SARS-COV-2 virus infection of Vero E2 cells at IC50 = 0.012 - 0.062 µg/ml.
Showed binding and blocking activity against South Africa and UK mutants.
Engineered Fc to reduce potential ADE risk.
Obtained CHO-K1 CMC clone with high expression titer.
Showed potent prophylactic and desired therapeutic efficacy in rhesus monkey disease model.
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02/03/21 GEM155 FPR2-specific ligand Atopic dermatitis/ Psoriasis, Dry eye disease, IBD (Inflammatory bowel disease), Asthma, Rheumatoid arthritis Topical, Eye drop, s.c. Peptide Phase 1 GEM155 is a small (7mer) lipidated peptide ligand for pro-resolving receptor FPR2 (N-formyl peptide receptor 2) involved in regulation of innate immune system and inhibition of ILC2 function (adaptive immune system). It also has anti-microbial effect for pathogenic bacteria through fusion with functional moiety. Efficacy is seen in animal models for the indications. CMC study is almost done. Toxicity study for topical usage and subcutaneous injection is going-on. Formulation for topical use is almost finished. Contact
01/29/21 GEM067 c-Kit inhibitor Diabetic macular edema & Retinopathy Oral Small molecules
Phase 2a completed -Inhibits stem cell factor-induced hyperpermeability
-Reverses retinal vascular leakage in STZ-induced diabetic rats
-Improved compliance to administration (oral) than anti-VEGF therapy (intra-vitreal injection)
-Applicable to non-responders to anti-VEGF therapy
-Repositioning of a marketed drug
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01/29/21 GEM105 Viscosupplementation Knee osteoarthritis Intra-articular Poly- saccharide
Marketing authorization Cross-linked sodium hyaluronate hydrogel with sodium hyaluronate fluid. Long-lasting and sustainable efficacy due to unique rheology of the cross-linked hydrogel. Injected only once and single injection shows comparable efficacy to a multiple-injection treatment. Obtained marketing authorization as a drug. Contact
01/13/21 GEM239 Activation of Treg and downregulating pro-inflammatory cytokines Psoriasis, Psoriatic arthritis, Rheumatoid arthritis, Ankylosing spondylitis, Crohn's and colitis Oral Small molecule Human POC completed Microbiomes are important for regulating human immune systems. GEM239 is a small molecule known as a gut microbial metabolite. It downregulates pro-inflammatory cytokines, and promotes differentiation of anti-inflammatory Treg cells. Human POC study in small number of psoriasis patients has been done and significant treatment effects have been seen. FDA IND approved. Clinical trial starting in 30 patients. Formulation-science has been applied. Contact
01/06/21 GEM238 CSN5 inhibitor Cancer i.v. Peptide Preclinical - Identifying CDK2 binding regions within the CSN5 protein
- Specifically inhibits the binding between CSN5 and CDK2 in "small complex" that is specifically expressed in cancer cells.
- It is possible to specifically inhibit the growth of cancer cells while suppressing the effect on normal cells.
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01/04/21 GEM237 Autologous chondrocyte cell therapy for cartilage repair/regeneration Chondral and osteochondral articular lesions of the knee Arthro- scopic implan- tation Cell and scaffold Launch The autologous cartilage repair system (a device kit consisting of a bioabsorbable highly porous scaffold and an enzyme for processing removed a small amount of cartilage) is for one-step surgery. It does not require an ex vivo cell expansion process. Hyaline cartilage is regenerated and long-term effectiveness is superior to the marrow stimulation procedure.
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