Drug Candidate Marketplace

Drug Candidate Marketplace lists the information of drug candidates, therapeutic targets and drug discovery technologies. Visitors can use search functions based on the interests and needs and download the list. If you have a drug candidates, therapeutic targets and drug discovery technologies that you are interested in and would like to gain more information, please contact us by clicking the inquiry button. Additional information will be provided to you.

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Date Candidate Mechanism of action Indication Route Modality Development stage Note
06/26/20 GEM196 Potassium-Competitive Acid Blocker (P-CAB) Peptic ulcer Oral Small molecule Phase 2 completed Phase 3 is ongoing.P-CABs are the best treatment with better and fater efficay for gastric acid-related gastrointestinal diseases such as gastric and duodenal ulcer, GERD, NERD, ZES and etc.
GEM196 is a potentially best-in-class P-CAB
- Faster clinical benefit in phase 2 study compared with Lansoprazole for duodenal ulcer treatment.
- Rapid and high absorption, oral bioavailability in clinical study.
- Lower toxicity and better PK, PD than TAK-438.
- Acid stability- exempt acid protection
- Longer lasting-higher concentration on target site
- Less individual differences- isoenzyme CYP2C19 metabolism tiny dependence.
06/18/20 GEM-CDV06 A potent DNA-immunotherapy against SARS-CoV-2 COVID-19 Intra- venous Injection In vivo CAR-T Preclinical DNA vector with Anti-CoV-2 Receptors inserted into our original platform (TGEM052) and delivered through liposomes into lymph nodes. The plasmid moves into the nucleus of normal T-cells and converted to CAR.
Anti-CoV-2 CAR T-cells attack the virus and diseased cells and destroy them.
06/18/20 GEM195 A potent DNA-immunotherapy for MAGE A Triple Negative Breast Cancer (TNBC) Intra- muscular Injection DNA Plasmid Preclinical DNA vector with MAGE A inserted into our original platform (TGEM052) and delivered into muscle cells using intramuscular injections followed by electroporation. The plasmid moves into nucleus of muscle cells and starts to over-express MAGE A, eliciting an immune response that can target MAGE A on cancer cells and destroy them Contact
06/18/20 GEM194 PDE4 inhibitor Autoimmune dermal disorders (bullous pemphigoid, psoriatic arthritis) Oral Small molecule Phase 1 GEM194 is the best-in-class PDE4 inhibitor having potentially a wider therapeutic index compared to clinically efficacious and marketed PDE4 inhibitors such as apremilast and roflumilast. Bullous pemphigoid (BP) is chronic autoimmune skin disorder resulting in generalized, pruritic, bullous lesions in elderly patients currently treated with corticosteroids and multiple antibacterial agents. Anti-inflammatory profile of PDE4 inhibition associated with multiple immune- and inflammatory cells is anticipated to taper doses of systemic corticosteroid. Opportunities exist to extend clinical development for other inflammatory dermal indications such as psoriatic arthritis. Contact
06/18/20 GEM193 PDE4 inhibitor NASH Oral Small molecule Phase 1 GEM193 was efficacious in reducing plasma ALT levels, hepatic fibrosis area, TG levels in an animal model of NASH. In addition, GEM193 exhibited anti-obesity and anti-diabetic properties in vivo. PDE4 enzyme is expressed not only in disease-relevant cell population, but also in ubiquitously whole body and its inhibition results in anti-inflammatory, anti-fibrotic and anti-metabolic effects that fit favorable profile as a monotherapy for NASH. Contact
06/18/20 GEM192 Selective PI3Kα inhibitor Slow-flow vascular malformations Oral Small molecule IND Slow-flow vascular malformations including venous malformation, lymphatic malformation, Klippel-Trenaunay syndrome is abnormal clustering of blood vessels that occurs in children or young adults and are caused by PI3K pathway GOF mutation. By selectively inhibiting PI3Kα isoform, GEM192 inhibits angiogenesis, but not immune function resulting in better therapeutic effects and lower infectious risk. Phase 1/2 data for another indication demonstrate a favorable tolerability profile. Clinical development to be pursued with new pediatric formulation. Contact
06/18/20 GEM191 Potentiation of detrusor contraction Underactive bladde Oral Small molecule Phase 1 Detrusor underactivity is a main cause of underactive bladder, which causes multiple lower urinary tract symptoms such as residual urine and urinary tract infection. GEM191 potentiates detrusor contraction and shows no impact on bladder storage function or urethral function. Stratified analysis clearly indicates efficacy to reduce residual urine in patients with detrusor underactivity. Contact
06/15/20 GEM190 Lipase inhibition, α-amylase inhibition, aldehyde dehydrogenase (ALDH) activation and anti-oxidant capacity increase Overweight and obesity Alcohol and tobacco smoke toxicity Oral Natural product Clinical GEM190 is a combination of two purified plant extracts in a form of oral liquid food supplement developed for appetite and weight control. Also, it reduces alcohol and tobacco smoke toxicity by activation of aldehyde dehydrogenase (ALDH) and increasing anti-oxidant capacity. In overweight and obese patients, GEM190 showed significant suppression of appetite and reduction of body weight and body fat as well as it had a beneficial effect on fluid distribution during weight loss, as observed in 12-week treatment. Increased ALDH activity in PBMC was observed already after 24 hours after initiation of GEM190 administration. GEM190 may provide a salvage solution in populations known to be particularly susceptible to a build-up of excess acetaldehyde, such as having a ALDH2*2 genetic mutation. GEM190 claims are under two PCT applications. Contact
06/05/20 GEM-CVD05 Immune-modulate and slow down the hyperactive active immune system from attacking lung cells (and other solid organs) Prevention of Respiratory Falure by Treating Acute Respiratory Disease Syndrome Resulting from COVID-19 and other viral pandemics Refer to Note* Protein** Phase 3 ready*** 1. Treatment of blood/MSCs, Tregs, NK cells with GEM-CVD05 to improve their homing to patients’ lungs, thereby enabling those cells to slow down the hyperactive immune attack on the lungs to help prevent deaths from respiratory failure.
2. Treatment of cells such as stem cells enabling them to home/engraft more effectively to the bone marrow and accelerating immune reconstitution with ‘younger’ immune cells for improved viral infected cell killing.
*Infusion with blood, or MSCs, Tregs, NK cells to improve efficacy, safety and cost of care outcomes
**Used to treat MSCs, Blood, Tregs, NK cells , Stem Cells to Prevent deaths from respiratory failure
***Phase 2 study for other indication has been completed.
06/05/20 GEM189 Nanoliposome-encapsuled Radionucleotide *Recurrent Glioblastoma,**Multiple tumor Intra- tumoral Radio- nucleotide *Phase1, **Preclinical Radionuleotide in GEM189 is ideal one for the treatment of solid Tumors. It delivers a high dose of radiation directly to the tumor while sparing normal, healthy brain tissue, stays at the tumor for several days and Effect lasts for several days and then dissipates. No serious adverse events observed to date.
Key advantages over External Beam Radiation Therapy:
-At least 500 Gy,
-Single 4-day hospitalization
-Able to more effectively treat tumor margins
- Limited toxicity
-Able to verify successful delivery with SPECT scan